Young Man Has ‘Excessive’ Skin Wrinkling From Water in Incredibly Rare Medical Case

A man in his 20s developed “excessive wrinkling”; bright, white bumps; patches of thick skin on his hands whenever he immersed them in water. Doctors initially thought the condition might be a symptom of chronic eczema, but they later determined that the wrinkling was caused by a rare skin disease, according to a new report of his case.  


The disease, known as aquagenic syringeal acrokeratoderma (ASA), mostly occurs in young women, according to the report, which was published Wednesday (March 23) in the journal JAMA Dermatology.

It’s also fairly common in people with cystic fibrosis, a genetic disorder that affects hormone-producing glands in the body causes mucus-producing organs to produce abnormally thick, sticky mucus, according to the Genetic Rare Diseases Information Center (GARD). 

People with cystic fibrosis carry two defective copies of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, but even people who have just one copy of this gene who don’t have cystic fibrosis are prone to the condition, which hints that ASA may be partially caused by a genetic mutation.

That said, the exact cause of ASA is unknown, but theories suggest that the condition may have something to do with abnormal sweat glands, according to GARD.

In the case of the young man with wrinkly hands, he reported to the dermatology department at The First Hospital of China Medical University in Shenyang after having experienced this condition for three years. The skin of his hands would become thick, swollen, wrinkly scaly after being in water, these changes would be accompanied by an itchy, burning sensation.


Related: 27 oddest medical cases 

“It is easy to misdiagnose ASA as eczema when the clinical features first appear,” the man’s doctors noted in the report.

Previously, at a different clinic, the man had been diagnosed with chronic eczema intermittently treated with topical tretinoin ointment, which is often used to treat fine wrinkles, dark spots acne; he saw little improvement with this treatment, the report notes.

Although the ASA symptoms initially affected only his hands, the man noted that, in the past year a half or so, the condition had also spread to his wrists elbows.

“He attributed these changes to the need for washing hands frequently in the period of the COVID-19 epidemic,” doctors wrote in the report. Upon closer examination, the doctors determined that the sweat glands pores on the man’s hands would become unusually large dilated after exposure to water.

“The patient’s clinical process was quite interesting,” the authors of the new report wrote. “The lesions only appeared after immersion in water, disappeared about 30 minutes after drying, no lesions occurred with the absence of water contact.”


These short-lived symptoms are a telltale sign of ASA known as “hin the bucket sign.”

ASA usually affects the palms of the hands, but the man had an unusual case in that his palms were spared, “which, to our knowledge, has previously not been reported,” the authors noted.

The patient was treated with topical hydrocortisone urea ointment, which is both a corticosteroid a moisturizer, he was told to avoid unnecessary contact with water. “The symptoms had greatly improved after one month, he is still in follow-up as of this writing,” according to the case report.

Other common treatments for ASA include the common acne medications salicylic acid ointment tazarotene gel, which encourage skin cell turnover, aluminum chloride, which is used to control excessive sweating, according to the report. And “in most cases, it does not need any treatment resolves spontaneously,” according to GARD.

“The COVID-19 pandemic outbreak has brought changes in lifestyle, including long-term glove wearing frequent hwashing, causing longer duration of water contact,” the case report concluded.

“So dermatologists should be more aware of the prevalence of ASA help to prevent diagnose this condition during the pandemic period.”

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This article was originally published by Live Science. Read the original article here.


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